By Gregory S. Makowski
Volume forty seven within the the world over acclaimed Advances in medical Chemistry includes chapters submitted from major specialists from academia and medical laboratory technology. Authors are from a various box of medical chemistry disciplines and diagnostics starting from easy biochemical exploration to state of the art microarray expertise.
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Extra resources for Advances in Clinical Chemistry, Vol. 50
Turrini, A. Piga, P. Arese, Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait, Blood 104 (10) (2004) 3364–3371. H. Atkinson, K. Rockett, G. A. Bejon, A. A. , Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype, PLoS Med. 3 (5) (2006) e172. S. B. Tanowitz, M. P. Bilezikian, Pathophysiological insights into the cardiomyopathy of Chagas’ disease, Circulation 82 (6) (1990) 1900–1909.
The A-61C SNP, which is highly linked to the Hp 2 allele protects from clinical malaria disease in the subgroup of children between 36 and 72 months. Differences in the population prevalence of the A-61C SNP and perhaps other SNPs (C-101G) could explain the contradictory data in different populations. An underestimation of the Hp 2 allele may be caused by misclassifying the Hp 2ff and Hp 2ss subtypes as Hp 1 by the genotyping method by Yano et al. . Studies associated with a protective effect of Hp 2-2 are controversial because the inability to phenotype samples with low Hp concentration (Hp 0).
The concentration of Hp is considerably lower in fetal blood and increases after birth to reach adult levels by the age of 20 years . There is a decreased rate of gene transcription in the fetal liver compared with the adult liver . The cytokine, interleukin-6 (IL-6), a major inducer of the acute-phase reaction, strongly induces the expression of the Hp gene . Other cytokines, IL-1 and tumor necrosis factor regulate the Hp gene expression to a lesser extent . Because of its role as a hemoglobin (Hb) scavenging molecule, Hp plays a key role in iron metabolism.