Anaerobiosis and stemness : an evolutionary paradigm for by Zoran Ivanovic, Marija Vlaski-Lafarge

By Zoran Ivanovic, Marija Vlaski-Lafarge

Anaerobiosis and Stemness: An evolutionary paradigm presents a context for knowing the numerous complexities and evolutionary positive aspects of stem cells and the scientific implications of anaerobiosis stem cells. Combining theoretical and experimental wisdom, the authors supply a wide realizing of the way the absence or low focus of oxygen can play an influential function within the upkeep and self-renewal of stem cells and stem mobile differentiation. This figuring out has medical implications for the fields of regenerative medication, melanoma biology and transplantation, in addition to cellphone engineering and mobile treatment. Anaerobiosis and Stemness is a crucial source for stem phone and developmental biologists alike, in addition to oncologists, melanoma biologists, and researchers utilizing stem cells for regeneration.

  • Highlights the molecular and evolutionary gains of stem cells which lead them to so very important to all organic research
  • Explores equipment of isolation, characterization, activation, and upkeep of stem cells
  • Includes types for scientific software in regenerative medication, melanoma remedy, and transplantation

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The authors showed using Pimonidazole that the “hypoxic” conditions are detectable in the ependymal layer that lines the ventricle, and in a subpopulation of neurons throughout the SEZ and striatum. Inside the cell population restrained to a complex phenotypic fraction c-kit+ Sca-1+ Isl-1+ [74–77] or SP [78] (and exhibiting a similar functional complexity as HSC), the cardiac stem and progenitor cells are contained (for review, [79]). In this population, glycolytic cardiac progenitors (GCPs) that mainly use glycolysis, express HIF-1α, and display a multilineage differentiation potential were lodged in the epicardium and subepicardium as the cardiac hypoxic niche (for review, [80,81]).

93] Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 2010;7:150–61. [94] Perry JM, Li L. To be or not to be a stem cell: dissection of cellular and molecular components of haematopoietic stem cell niches. EMBO J 2012;31:1060–1. 4 What Can We Learn? 1 First Notions of Oxygenation Ex Vivo More than one century ago, Alexis Carrel reported the results of experiments aimed to maintain ex vivo tissue of chicken embryo and fetal connective tissue, heart tissue, and ­portal vein tissue as well as the Rous sarcoma cells [1].

In: Piiper J, Goldstick TK, Meye M, editors. Oxygen transport to tissue. New York: Plenum Press; 1990. p. 745–50. The “Hypoxic” Stem Cell Niche 33 [6] Jauniaux E, Kiserud T, Ozturk O, West D, Hanson MA. Amniotic gas exchange and acid—base status during acute maternal hyperoxemia and hypoxemia in the early fetal sheep. Am J Obstet Gynecol 2000;182:661–5. [7] Eskes T, Jongsma HW, Houx PCW. Percentiles for gas values in human umbilical cord blood. Eur J Obstet Gynecol Reprod Biol 1983;14:341–6. [8] Yeomans ER, Hauth JC, Gilstrap 3rd LC, Strickland DM.

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