Analysis of Growth Factor Signaling in Embryos (Methods in by Malcolm Whitman, Amy Sater

By Malcolm Whitman, Amy Sater

Developmental biologists were pushed to enquire progress issue signaling in embryos so one can comprehend the regulatory mechanisms underlying a given developmental strategy. therefore, it truly is severe to discover the technical tools and experimental designs for development issue signaling in embryos. targeting particular pathways or pathway elements, research of development issue Signaling in Embryos offers the equipment and instructions for experimental layout to review significant features of mobilephone signaling in vertebrate embryos. The e-book covers a large variety of issues in signaling and a number of present version organisms. part I explores particular signaling pathways or pathway elements. during this part, a few chapters spotlight the biochemistry of signaling pathways in the course of improvement, that is usually special from that saw in mobile tradition platforms. part II discusses ionic regulatory mechanisms and the 2 chapters in part III learn methods of investigating gene rules according to extracellular signs. ultimately, part IV addresses rising concepts that facilitate built-in analyses of mobilephone signaling in vivo in embryonic platforms. that includes contributions from specialist researchers, research of progress issue Signaling in Embryos will offer a beginning for extra explorations of the mobile regulatory mechanisms governing vertebrate embryonic improvement.

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Xanthos, J. , The roles of three signaling pathways in the formation and function of the Spemann organizer, Development 129 (17), 4027–43, 2002. 119. Xanthos, J. , Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis, Development 128 (2), 167–80, 2001. 120. , β-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach, Dev Biol 222 (1), 124–34, 2000. 121. , Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors, Development 126 (24), 5759–70, 1999.

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104. Cong, F. , Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin, Proc Natl Acad Sci U S A 101 (9), 2882–7, 2004. 105. , Nucleo-cytoplasmic shuttling of Axin, a negative regulator of the Wnt-β-catenin pathway, J Biol Chem 279 (7), 5263–7, 2004. 106. Henderson, B. , Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover, Nat Cell Biol 2 (9), 653–60, 2000. 107. Townsley, F. , Pygopus and Legless target Armadillo/βcatenin to the nucleus to enable its transcriptional co-activator function, Nat Cell Biol 6 (7), 626–33, 2004.

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