Anticoagulants, Antiplatelets, and Thrombolytics by Shaker A. Mousa

By Shaker A. Mousa

This sensible assortment presents a complete replace on clinically proper in vitro and in vivo versions of thrombosis and hemostasis for the invention and trying out of antithrombotics, and summarizes contemporary improvement in prescribed drugs for the prevention and remedy of assorted thromboembolic problems. subject matters of the 17 contributions comprise low molecular weight heparins, antithrombotic medicinal drugs for the therapy of heparin-induced thrombocytopenia, directions for the analysis of deep venous thrombosis and pulmonary embolism, the improvement of either small and big animal versions, the features of issue Xa inhibitors, and the advance of healing applicants in response to telephone adhesion molecules.

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1991) Prevention of perioperative deep vein thrombosis in general surgery: a multicenter double blind study comparing two doses of logiparin and standard heparin. Br. J. Surg. 78, 412–416. 11. Ryan, K. , Lane, D. , Ireland, H. , and Curtis, J. R. (1991) Dose finding study of a low molecular weight heparin, tinzaparin, in haemodialysis. Thromb. Haemostasis 66(3), 277–282. 12. Pedersen, P. , Østergaard, P. , and Mätzsch, T. (1991) Pharmacokinetics of low molecular weight heparin, logiparin, after intravenous and subcutaneous administration to healthy volunteers.

Because they are polypharmacological agents, these drugs are expected to find uses in several other clinical indications such as inflammatory diseases and cancer. Additional pharmacological studies and well-designed clinical trials in which various pharmacokinetic and pharmacodynamic parameters are studied will provide addiFrom: Methods in Molecular Medicine, vol. 93: Anticoagulants, Antiplatelets, and Thrombolytics Edited by: S. A. , Totowa, NJ 35 CH04,35-48,14pgs 36 9/5/03 11:01 AM Page 36 Mousa Fig.

1995) Comparative real-time effects on platelet adhesion and aggregation under flowing conditions of in vivo aspirin, heparin, and monoclonal antibody fragment against glycoprotein IIb-IIIa. Circulation 91, 1354–1362. Mousa, S. , Abulencia, J. , McCarty, O. J. , Turner, N. , and Konstantopoulos, K. (2002) Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis. J. Cardiovasc. Pharmacol. 39, 552–560.

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