Artificial Oxygen Carrier: Its Frontline (Keio University by oriexm

By oriexm

Whereas a competent provide of donated blood is key in sleek medication, it is still the case that blood transfusion comes with its personal difficulties, akin to infectious illnesses, immunological hostile reactions, and problems with long term garage and transportation of blood parts. as a way to fixing those difficulties, constructing an appropriate blood replacement has been a big objective for many years. man made Oxygen provider: Its entrance Line is a compilation of stories at the options in the back of man made oxygen vendors, in addition to the hot discoveries within the box that have been provided in the course of the thirteenth Keio foreign Symposium for all times technology and medication. This quantity describes beneficial subject matters, together with man made pink blood cells, changed haemoglobin, perfluorocarbons, and haemoglobin vesicles. It explains state of the art advancements in synthetic oxygen service study and may be a precious source to all excited by the sphere.

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Additional resources for Artificial Oxygen Carrier: Its Frontline (Keio University International Symposia for Life Sciences and Medicine, Vol. 12) (Keio University International Symposia for Life Sciences and Medicine)

Example text

Barnikol and colleagues in Germany have been studying the preparation of porcine hemoglobin hyperpolymers. Conjugated Hemoglobin Hb has also been cross-linked to polymers to form an insoluble conjugated Hb [9,10]. This approach has been extended to produce a soluble conjugated Hb formed by cross-linking individual Hb molecules to soluble polymers such as dextran [19], polyoxyethylene [20] and polyethylene glycol (PEG) [21]. This is in ongoing clinical trials [22]. More recently, a new Maleimide PEGhemoglobin [23] has been developed and is now in Phase II clinical trials.

Traditional thinking has been that the p50 of cell-free O2 carriers should be the same as the p50 of normal human blood in order to deliver oxygen ade- 100 Saturation % 80 60 H+ CO2 2,3-DPG Temperature P50 40 20 0 10 20 30 40 50 60 70 80 90 100 PO2, torr Fig. 1. The normal whole blood oxygen equilibrium curve (OEC). p50 is the pO2 at which hemoglobin is half-saturated with O2. The principal effectors that alter the position and shape of the curve under physiological conditions are indicated. From [3] p50 in Oxygen Delivery 41 quately to tissue.

By doing this, the useful O2-carrying life of hemoglobin is prolonged from a few hours to more than 100 days. Without such protection, the body could scarcely produce enough hemoglobin to support itself under basal conditions. 3. Tissue must be protected from the toxic effects of iron-containing heme. Oxygen transporters throughout nature are heme proteins. Protective mechanisms must be in place to prevent direct tissue damage by iron oxidation. M. Winslow This is achieved, again, but inclusion of the protein within the red cell, which not only prevents degradation, but protects it from oxidation by enzymatic reducing systems.

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