Bioorganic and Medicinal Chemistry of Fluorine by Jean-Pierre Bégué

By Jean-Pierre Bégué

  • offers a radical evaluation of the position of fluorine in pharmaceutical technology and improvement
  • contains chapters on fluorinated analogues of traditional items, fluorinated amino acids and peptides, and derivatives of sugars
  • Classifies advertised and in-development fluorinated prescription drugs in line with their healing periods
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    Bioorganic and Medicinal Chemistry of Fluorine

    Presents an intensive evaluation of the function of fluorine in pharmaceutical technology and improvement contains chapters on fluorinated analogues of typical items, fluorinated amino acids and peptides, and derivatives of sugars Classifies advertised and in-development fluorinated prescription drugs in line with their healing periods

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    Indeed, because of the great reactivity of carbanions toward elimination of a fluoride ion, they may have short lifetimes: a-fluorinated carbanions easily undergo a-elimination processes to carbenes, while b-fluorinated carbanions undergo belimination reactions. 41 Consequently, the corresponding organometallic species (Li, Mg) cannot be used in organic synthesis. When the carbon-metal bond is close to a covalent bond, the anionic species is more stable, but has almost no reactivity toward electrophiles.

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