Cancer Cachexia by Egidio Del Fabbro, Akio Inui, Florian Strasser, David Blum,

By Egidio Del Fabbro, Akio Inui, Florian Strasser, David Blum, Hajime Suzuki

Cancer Cachexia is a concise, absolutely illustrated guide written with the purpose of accelerating wisdom of melanoma cachexia and highlighting most sensible perform prognosis, remedy, and administration concepts for this devastating affliction. this is often one other identify within the ongoing Springer Healthcare melanoma Supportive Care Series.

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There are few trials that have evaluated the effect of pharmacological treatments for early satiety, and symptom responses to prokinetics do not necessarily correlate with objective response [17]. Metoclopramide is used most frequently to treat satiety and there is evidence that metoclopramide improves early satiety in patients with cancer and gastroparesis [18]. Nelson and colleagues [19] reported the use of metoclopramide in 20 patients with advanced cancer; although appetite, bloating, belching, and nausea improved, only 4 out of 18 individuals saw an improvement in early satiety.

Qual Life Res. 2000;9:1137-1146. 41 Guyatt GH, Osoba D, Wu AW, Wyrwich KW, Norman GR. Methods to explain the clinical significance of health status measures. Mayo Clin Proc. 2002;77:371-383. 42 Lai JS, Cella D, Peterman A, Barocas J, Goldman S. Anorexia/cachexia-related quality of life of children with cancer. Cancer. 2005;104:1531-1539. 40 • C an c e r c ac h e x i a 43 Robinson Jr DW, Eisenberg DF, Cella D, Zhao N, de Boer C, DeWitte M. The prognostic significance of patient-reported outcomes in pancreatic cancer cachexia.

2011;343:d4920. 20 Cherny NI, Abernethy AP, Strasser F, Sapir R, Currow D, Zafar SY. Improving the methodologic and ethical validity of best supportive care studies in oncology: lessons from a systematic review. J Clin Oncol. 2009;27:5476-5486. 21 Zafar SY, Currow DC, Cherny N, Strasser F, Fowler R, Abernethy AP. Consensus-based standards for best supportive care in clinical trials in advanced cancer. Lancet Oncol. 2012;13:e77-82. 22 Ebner N, Werner CG, Doehner W, Anker SD, von Haehling S. Recent developments in the treatment of cachexia: highlights from the 6th Cachexia Conference.

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