By Constance Hammond
This new, completely revised fourth variation is the single present, tested and authoritative textual content concentrating on the mobile and molecular body structure of nerve cells. figuring out the functioning of the neuron, the elemental mobile of the primary frightened procedure calls for a transparent realizing of the mobile and molecular body structure of the neuron. The booklet is speculation pushed instead of simply featuring the evidence, and the content material is firmly in line with a variety of experiments played by means of the pinnacle specialists within the box. whereas the publication does disguise the $64000 proof, it additionally offers the heritage for a way researchers arrived at this information to supply a context for the sphere. It teaches not just how excitable cells paintings intimately, but additionally the right way to build and behavior clever examine experiments. This e-book promotes a true knowing of the functionality of nerve cells that's precious for training neurophysiologists and scholars in a graduate-level path at the subject alike.
- 70% new or up-to-date fabric in complete colour all through, with greater than 350 conscientiously chosen and built illustrations
- Fifteen appendices describing neurobiological strategies are interspersed within the text
- Accompanying teacher site with routines and spouse site available
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Additional resources for Cellular and Molecular Neurophysiology, Fourth Edition
A remarkable property of Schwann cells is their ability to promote the regeneration of peripheral nerve cells. It has long been known that cut peripheral nerves can, within certain limits, regrow and reinnervate deafferented regions while central axons are not capable of this. The substantial regenerative capacity of the Schwann cells is driven by their ability to dedifferentiate following axonal injury, to divide and produce axonotrophic factors. This property of regeneration is due in large part to an enabling effect of Schwann cells on axon regrowth.
The lipid bilayer is a barrier for the diffusion of ions and most polar molecules. The first demonstrations of ionic fluxes across plasma membrane by Hodgkin and Keynes (1955) were based on the use of radioisotopes of K+ or Na+ ions. Experiments were conducted on the isolated squid giant axon. When this axon is immersed in a bath containing a control concentration of radioactive *Na+ (24Na+) instead of cold Na+ (22Na+), *Na+ ions constantly appear in the cytoplasm. This *Na+ influx is not affected by dinitrophenol (DNP), a blocker of ATP synthesis in mitochondria.
2013. Organization and maintenance of molecular domains in myelinated axons. J. Neurosci. Res. 91, 603–622. , 2005. Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath. Neuron Glia Biol. 1, 1–14. , 2014. Oligodendrogenesis in normal and pathological brain. Front. Neurosci. 8, 145. , 2005. Physiology of microglial cells. Brain Res. Brain Res. Rev. 48, 133–143. , 2014. Glial biology in learning and cognition. Neuroscientist 20, 426-431. , 2006.