Clinical Evidence: Cardiovascular Disorders ; The by Clinical Evidence

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Extra resources for Clinical Evidence: Cardiovascular Disorders ; The International Source of the Best Available Evidence for Cardiovascular Health Care

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SearchTerm=Stroke+prevention See glossaryẦ Key Messages Prevention of embolism ¶ Antithrombotic treatment before cardioversion We found no RCTs on use of aspirin, heparin, or warfarin as thromboprophylaxis before attempted cardioversion in acute atrial fibrillation. Rhythm conversion ¶ Flecainide Five RCTs found that intravenous flecainide increased the proportion of people who reverted to sinus rhythm within 1–24 hours compared with placebo. Flecainide was associated with serious adverse events such as severe hypotension and torsades de pointes.

3 Likely to be beneficial Clopidogrel/ticlopidine . . . . . . . 4 Intravenous glycoprotein IIb/IIIa inhibitors. 4 ANTI-ISCHAEMIC TREATMENTS Unknown effectiveness Beta-blockers (for myocardial infarction or death) . . . . . . . . . . . . 8 Nitrates (for myocardial infarction or death) . . . . . . . . . . . . . 67 Likely to be ineffective or harmful Oral glycoprotein IIb/IIIa inhibitors . . . . 5 Unlikely to be beneficial Calcium channel blockers .

6 Verapamil . . . . . . . . 15 RATE CONTROL Likely to be beneficial Digoxin . . . . . . . . . 15 Diltiazem . . . . . . . . . 16 Timolol . . . . . . . . . 17 Verapamil . . . . . . . . 18 Unknown effectiveness Amiodarone . . . . . . . . 15 Sotalol . . . . . . . . . searchTerm=Stroke+prevention See glossaryẦ Key Messages Prevention of embolism ¶ Antithrombotic treatment before cardioversion We found no RCTs on use of aspirin, heparin, or warfarin as thromboprophylaxis before attempted cardioversion in acute atrial fibrillation.

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