Congenital Heart Diseases: The Broken Heart: Clinical by Silke Rickert-Sperling, Robert G. Kelly, David J. Driscoll

By Silke Rickert-Sperling, Robert G. Kelly, David J. Driscoll

This e-book presents complete insights into congenital center sickness from embryonic improvement via to medical beneficial properties, together with human genetics and our present wisdom of the underlying molecular pathways. it truly is divided into 3 elements: an advent to the advance of the center and its vessels, an outline of the molecular pathways affecting the improvement of varied cardiovascular constructions, and a major part targeting the different sorts of structural and nonstructural congenital middle illnesses, together with their medical good points, underlying genetic changes and comparable animal versions and pathways. Taken jointly those chapters, which have been written by way of and for clinicians and researchers, supply an built-in and state-of-the-art source for all those that are looking to research extra approximately either the medical facets and the genetic and molecular foundation of congenital center disease.

Show description

Read Online or Download Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways PDF

Similar developmental biology books

The Lives of the Brain: Human Evolution and the Organ of Mind

Notwithstanding we've got different distinguishing features (walking on legs, for example, and relative hairlessness), the mind and the habit it produces are what really set us except the opposite apes and primates. and the way this three-pound organ composed of water, fats, and protein became a mammal species into the dominant animal in the world this present day is the tale John S.

Morphogenesis: The Cellular and Molecular Processes of Developmental Anatomy (Developmental and Cell Biology Series)

This well timed account offers a entire modern research of morphogenetic procedures in vertebrate and invertebrate embryos. Morphogenesis, the new release of tissue association in embryos, is an more and more very important topic. this can be in part as the options for investigating many morphogenetic mechanisms have only in the near past turn into on hand and in part simply because learning the genomic foundation of embryogenesis calls for an knowing of the developmental phenotype.

The ovary of Eve: egg and sperm and preformation

The Ovary of Eve is a wealthy and sometimes hilarious account of 17th- and eighteenth-century efforts to appreciate belief. In those early years of the clinical Revolution, the main clever women and men of the day struggled to come back to phrases with the origins of latest existence, and one theory—preformation—sparked an intensely heated debate that persisted for over 100 years.

The Impact of New Ideas

Quantity eleven starts off with a well timed review of self psychology and intersubjectivity conception, with unique contributions by way of Carveth, Trop, and Powell, and a serious observation by means of P. Ornstein. scientific reports span the transferences, the complementarity of person and staff treatment, the termination section, and a number of character affliction.

Extra resources for Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways

Sample text

Trabeculae are present in the mouse heart from midgestation to fetal stages when a process of compaction generates the definitive ventricular wall. Failure of this step results in noncompaction cardiomyopathy. 5, a third cell layer, the epicardium (Chap. 6), covers the external surface of the heart (Fig. 1i). The epicardium originates in the pro-epicardial organ and forms an epithelium from which cells undergo a mesenchymal transition and invade the myocardium, giving rise to smooth muscle cells associated with coronary arteries and cardiac fibroblasts.

Sadler TW, Langman J (2012) Langman’s Medical Embryology, 12th edn. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia 5. Harvey RP (2002) Patterning the vertebrate heart. Nat Rev Genet 3:544–556 6. Srivastava D (2006) Making or breaking the heart: from lineage determination to morphogenesis. Cell 126:1037–1048 1 Cardiac Development and Animal Models of Congenital Heart Defects 9 7. Kelly RG (2012) The second heart field. Curr Top Dev Biol 100:33–65 8. Rochais F, Mesbah K, Kelly RG (2009) Signaling pathways controlling second heart field development.

The electrical signal initiates apical ventricular contraction through the atrioventricular bundle, bundle branches, and Purkinje fiber network. Conductive cells are specialized myocytes and share common progenitor cells with nonconducting myocytes [16]. Defects in the establishment of the electrical wiring of the heart result in arrhythmias and conduction blocks. The Purkinje fiber system develops adjacent to the ventricular lumen in trabecular myocytes, transient projections of myocardium that form by signal exchange between the myocardial wall and endocardium.

Download PDF sample

Rated 4.09 of 5 – based on 15 votes