By Silke Rickert-Sperling, Robert G. Kelly, David J. Driscoll
This e-book presents complete insights into congenital center sickness from embryonic improvement via to medical beneficial properties, together with human genetics and our present wisdom of the underlying molecular pathways. it truly is divided into 3 elements: an advent to the advance of the center and its vessels, an outline of the molecular pathways affecting the improvement of varied cardiovascular constructions, and a major part targeting the different sorts of structural and nonstructural congenital middle illnesses, together with their medical good points, underlying genetic changes and comparable animal versions and pathways. Taken jointly those chapters, which have been written by way of and for clinicians and researchers, supply an built-in and state-of-the-art source for all those that are looking to research extra approximately either the medical facets and the genetic and molecular foundation of congenital center disease.
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Extra resources for Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways
Trabeculae are present in the mouse heart from midgestation to fetal stages when a process of compaction generates the deﬁnitive ventricular wall. Failure of this step results in noncompaction cardiomyopathy. 5, a third cell layer, the epicardium (Chap. 6), covers the external surface of the heart (Fig. 1i). The epicardium originates in the pro-epicardial organ and forms an epithelium from which cells undergo a mesenchymal transition and invade the myocardium, giving rise to smooth muscle cells associated with coronary arteries and cardiac ﬁbroblasts.
Sadler TW, Langman J (2012) Langman’s Medical Embryology, 12th edn. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia 5. Harvey RP (2002) Patterning the vertebrate heart. Nat Rev Genet 3:544–556 6. Srivastava D (2006) Making or breaking the heart: from lineage determination to morphogenesis. Cell 126:1037–1048 1 Cardiac Development and Animal Models of Congenital Heart Defects 9 7. Kelly RG (2012) The second heart ﬁeld. Curr Top Dev Biol 100:33–65 8. Rochais F, Mesbah K, Kelly RG (2009) Signaling pathways controlling second heart ﬁeld development.
The electrical signal initiates apical ventricular contraction through the atrioventricular bundle, bundle branches, and Purkinje ﬁber network. Conductive cells are specialized myocytes and share common progenitor cells with nonconducting myocytes . Defects in the establishment of the electrical wiring of the heart result in arrhythmias and conduction blocks. The Purkinje ﬁber system develops adjacent to the ventricular lumen in trabecular myocytes, transient projections of myocardium that form by signal exchange between the myocardial wall and endocardium.