Development of Dopaminergic Neurons by Umberto Di Porzio, Roberto Pernas-Alonso, Carla

By Umberto Di Porzio, Roberto Pernas-Alonso, Carla Perrone-Capano

The catecholamine dopamine (DA) performs a key function within the body structure of such a lot vertebrate and invertebrate organisms. as well as its function as a transmitter within the apprehensive method, it has a task in improvement. The quite few DA neurons within the mammalian mind have vital roles in lots of neural features together with high quality motor integration, neuroendocrine hormone free up, cognition, emotive behaviors, male sexual habit and doubtless reminiscence. huge info has been gathered at the complicated mechanisms of midbrain patterning, dopamine phenotype induction and maturation and the function of epigenetic elements in speciation, improvement and upkeep of midbrain dopaminergic functionality. between different matters, this publication describes the molecular and morphological occasions required for the induction of the neural plate for the institution of neighborhood identities. wisdom of the complicated integrative features exerted via dopamine on the right track cells has been promoted through the ! molecular characterization of the DA receptor gene kin. The chapters amassed during this booklet supply new and large info that would permit scientists to extra their wisdom of the fundamental mechanisms underlying DA neuron improvement and serve as.

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A homeodomain gene Ptx 3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Proc Natl Acad Sci USA 1997; 94:13305-13310. CHAPTER 3 Development of Midbrain Dopaminergic Neurons Carla Perrone-Capano, Roberto Pernas-Alonso and Umberto di Porzio T he catecholamine dopamine (DA) plays a key role in the physiology of most vertebrate and invertebrate organisms. 3,4 In rodents, neurons arising from the substantia nigra project to the striatum (corresponding to the caudate-putamen in primates) and receive innervation from multiple structures in the diencephalon and telencephalon.

111. Park H, Platt K, Matise M et al. Genetic analysis of the role of gli genes during embryogenesis in double mutant mice. Develop Biol 1998; 198:217-343. 112. Crossley PH, Martin GR. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. De- velopment 1995; 121:439-451. 113. Meyers EN, Lewandowski M, Martin GR. An Fgf8 mutant allelic series generated by Creand Flp-mediated recombination. Nature Genetics 1998; 18:136-141.

53 Mice with a moderate reduction in the levels of FGF8113 do generate a population Specification of Dopaminergic Neurons: Inductive Factors and Their Receptors 25 Fig. 6. Location of Early Gene Markers and Mature Neurons Along the A-P axis of the Rat Embryo. (A-C) Parasagittal sections of the E14 rat ventral mid/hindbrain stained for: (A) Fgf8 and Shh mRNA; (B) Fgf8 mRNA (arrow) and TH+ DA neurons (TH); (C) TH and serotonin (5HT). The arrows mark the mid-hindbrain boundary and the site of Fgf8 expression.

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