Prostaglandins, Leukotrienes and Other Eicosanoids: From by Friedrich Marks, Gerhard Fürstenberger

By Friedrich Marks, Gerhard Fürstenberger

Polyunsaturated fatty acids are crucial for human phone metabolism. As precursors of a truly huge and intensely flexible relations of signaling compounds they play a key position in intracellular communique. Eicosanoids represent some of the most ample and renowned subfamilies of those fatty acid derivatives that are shaped essentially alongside oxidative pathways. Prostaglandins, leukotrienes, and similar eicosanoids have a modulatory functionality in mammalian cells and are accountable for tissue responses resembling irritation or wound fix. expanding job in eicosanoid study sheds new mild on modern-day most typical illnesses together with atherosclerosis, melanoma, Alzheimer's, bronchial asthma, and rheumatic ailments. the hot advances have already got far-reaching implications in medication. This exact account, written through top specialists, covers the ground-breaking advancements in contemporary eicosanoid study. the subjects span eicosanoid biogenesis, new facets in their pathophysiology, for instance their impact at the cardiovascular procedure, in addition to the medical software of man-made eicosanoids and their antagonists. Researchers and scholars operating in biochemistry or in pharmaceutical, physiological, medicinal and neurochemistry will worth this informative creation to 1 of the main swiftly constructing fields in mobilephone biology.

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Prostaglandins, Leukotrienes and Other Eicosanoids: From Biogenesis to Clinical Application

Polyunsaturated fatty acids are crucial for human cellphone metabolism. As precursors of a really huge and very flexible kinfolk of signaling compounds they play a key position in intracellular verbal exchange. Eicosanoids represent probably the most considerable and well known subfamilies of those fatty acid derivatives that are shaped basically alongside oxidative pathways.

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E. 1I activation) ‘relaxant receptors’ (acting via G, activation) and ‘inhibitory receptors’ (acting via G , i activation). feicosunoids in mummals 37 According to expression studies prostanoid receptors may couple with more than one G protein type [ 152,1531. Whether this functional promiscuity also holds true for normal tissues in vivo remains to be shown. The G protein-controlled pathways of intracellular signal processing regulate the activity and de now synthesis of a wide variety of proteins including ion channels, receptors, enzymes, cytoskeletal compounds and transcription factors.

3 Mammalian eicosanoids 21 enzymatically to the corresponding a,B,-dihydroxy eicosatrienoic acids (DHETs). 4) and vasodilatation in other organs. However, specific cellular epoxide receptors have not yet been identified so that the mechanisms of action of these eicosanoids are largely unknown. 3). For more information on the synthesis, metabolism and (patho)physiological functions of cytochrome P-450-derived eicosanoids the reader is referred to Chapter 6. -_. * 1 3 COOH rn! a%bydroxyhtion(2) 1 - 3 1 3 1 3 2 16-HETE 17-HETE lEHETE 19-HETE 20-HETE 2 hydroxylationwith double bond migration (3) 5-HETE EHETE 9-HETE 11-HETE If R-HETE 15R-HETE Figure 1-9.

E. production of cyclic AMP and diacylglycerolhnositol-1,4,5-trisphosphate (DAG/IPx) I102,149-151]. These two systems frequently act in an antagonistic man- 36 I Arachidonic acid and companions: an abundant source cfbiological signals ner which easily explains the complexity of eicosanoid functions. Thus, Gq,lI activation results-via IP3 release and Ca2’ mobilization-in smooth muscle constriction and activation of secretory processes, whereas cyclic AMP released upon G, activation may control opposing reactions.

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